December 2011

The MCG CNV Database provides copy number variant ( CNV ) and loss of heterozygosity ( LOH ) detected through microarray analyses in healthy Japanese by our in-house BAC-based arrays, so-called MCG arrays¹⁾, and SNP array ( illumina, HumanOmniExpress Beadchip ). The MCG CNV Database shows an incidence of CNV and LOH in the Japanese healthy population and can be of assistance to estimate a pathogenicity of CNV or LOH detected in subjects having possible involvement of cryptic genomic aberrations behind their pathogenesis.

Reference

1) Inazawa J, Inoue J, Imoto I. Comparative genomic hybridization (CGH)-arrays pave the way for identification of novel cancer-related genes. 2004. Cancer Sci 95: 559-563.

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Collaborators

• Nobuyuki Hamajima, Professor
  Department of Preventive Medicine, Nagoya University Graduate School of Medicine
• Dr. Sueli Mieko Oba-Shinjo
  Laboratory of Molecular Biology, Department of Neurology, School of Medicine, São Paulo University, São Paulo, Brazil
• Dr. Lucy Sayuri Ito
  Japanese Brazilian Health Professional Volunteer Group, São Paulo, Brazil

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Contributors to the construction of this database are follows;

• *Professor Johji Inazawa
• Professor Issei Imoto
• Dr. Shin Hayashi
• Ms Ayako Takahashi
• Ms Rumi Mori

*Corresponding to this database

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The construction of these databases was supported in part by
New Energy and Industrial Technology Development Organization ( NEDO ).